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Synlett 2001; 2001(3): 0382-0384
DOI: 10.1055/s-2001-11404
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Synthesis of 1,3,4-Oxadiazoles Using Polymer-supported Reagents

Christopher T. Brain* , Shirley A. Brunton
  • *Novartis Institute for Medical Sciences, 5 Gower Place, London, WC1E 6BN, UK; Fax+ 44(0)20 73 87 41 16; E-mail: christopher.brain@pharma.novartis.com
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Publication Date:
31 December 2001 (online)

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The preparation of a novel polystyrene-supported dehydrating agent and its application to the synthesis of 1,3,4-oxadiazoles under thermal and microwave conditions is described. An alternative procedure using tosyl chloride and P-BEMP is also presented.

oxadiazoles - polymer-supported reagents - cyclization - microwaves