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Synlett 2001; 2001(3): 0357-0360
DOI: 10.1055/s-2001-11397
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Stereoselective Double Ring Closing Metathesis Reactions in the Synthesis of Spirocyclic Compounds

Debra J. Wallace* , Paul G. Bulger, Derek J. Kennedy, Michael S. Ashwood, Ian F. Cottrell, Ulf-H. Dolling
  • *Department of Process Research, Merck Sharp & Dohme Research Laboratories, Heerford Road, Hoddesdon, Hertfordshire, EN11 9BU, UK; Fax + 44 1992 47 04 37; E-mail: debra wallace@merck.com
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Publication Date:
31 December 2001 (online)

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The double ring closing metathesis reaction of α-hydroxyester derived tetraenes 4 proceed to give spirocyclic dihydropyrans in excellent yield and with good selectivity. The first examples of diastereoselective double RCM reactions to give medium ring spirocycles are also reported.

ring closing metathesis - stereoselective - spirocyclic compounds