PDF herunterladen
Synlett 2001; 2001(3): 0379-0381
DOI: 10.1055/s-2001-11390
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile New Method for the Two-step Substitution of Hydroxy Groups in Primary Alcohols for Trifluoromethyl and Pentafluoroethyl Moieties

Dmitri V. Sevenard* , Peer Kirsch, Gerd-Volker Röschenthaler, Valery N. Movchun, Alexander A. Kolomeitsev
  • *Institut für Anorganische und Physikalische Chemie, Universität Bremen, Leobener Strasse, 28334 Bremen, Germany; Fax+ 49-421-218-42-67; E-mail: alex@chemie.uni-bremen.de
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

In an efficient procedure the nucleophilic trifluoromethylation and pentafluoroethylation of alkyl triflates using (trifluoromethyl)- and (pentafluoroethyl)trimethylsilane in the presence of anhydrous tetramethylammonium fluoride is achieved giving 71-80% isolated yields.

perfluoroalkylation - (perfluoroalkyl)trimethylsilane - anhydrous tetramethylammonium fluoride - nucleophilic substitution