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Synlett 2001; 2001(3): 0379-0381
DOI: 10.1055/s-2001-11390
DOI: 10.1055/s-2001-11390
letter
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A Facile New Method for the Two-step Substitution of Hydroxy Groups in Primary Alcohols for Trifluoromethyl and Pentafluoroethyl Moieties
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Publication History
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/synlett/200103/lookinside/thumbnails/10.1055-s-2001-11390-1.jpg)
In an efficient procedure the nucleophilic trifluoromethylation and pentafluoroethylation of alkyl triflates using (trifluoromethyl)- and (pentafluoroethyl)trimethylsilane in the presence of anhydrous tetramethylammonium fluoride is achieved giving 71-80% isolated yields.
perfluoroalkylation - (perfluoroalkyl)trimethylsilane - anhydrous tetramethylammonium fluoride - nucleophilic substitution