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Synlett 2001; 2001(2): 0251-0253
DOI: 10.1055/s-2001-10765
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An Efficient and Facile Synthesis of 2-Chloro-3-formyl Quinolines from Acetanilides in Micellar Media by Vilsmeier-Haack Cyclisation

M. M. Ali* ,  Tasneem, K. C. Rajanna, P. K. Sai Prakash
  • *Nawab Shah Alam Khan Centre for Post Graduate Studies and Research, Anwar-ul-uloom College, Hyderabad-500 001; E-mail: ksrmk§satyamonline.com
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Publication History

Publication Date:
31 December 2001 (online)

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Acetanilides efficiently undergo Vilsmeier-Haack cyclisation in micellar media to afford 2-chloro-3-formyl quinoline derivatives in good yields. This procedure works efficiently in CTAB (cetyl trimethyl ammonium bromide), SDS (sodium dodecyl sulphate) and TX (Triton-X-100) media under reflux conditions particularly from deactivated acetanilides in good yields.

acetanilides - micelles - 2-chloro-3-formyl quinolines - Vilsmeier-Haack cyclisation - POCl3-DMF