Planta Med 2000; 66(8): 778-780
DOI: 10.1055/s-2000-9779
Letter
© Georg Thieme Verlag Stuttgart · New York

Quantitative Changes of Dianthrones, Hyperforin and Flavonoids Content in the Flower Ontogenesis of Hypericum perforatum

Daniela Tekel'ová1,*, Miroslav Repčák2 , Erika Zemková1 , Jaroslav Tóth1
  • 1 Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia
  • 2 Department of Experimental Botany and Genetics, Faculty of Natural Sciences, P. J. Šafárik University, Košice, Slovakia
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Samples of Hyperici herba were obtained by harvesting Hypericum perforatum L. in different plant development stages. The relation of flower development phases in the drug's flower fraction was examined. The HPLC method was then employed for the analysis of the content of secondary metabolites in different flower ontogenesis phases. The content of dianthrones, derivatives of quercetin and hyperforin increased from the first bud phases (0.29 %, 0.80 %, and 2.47 %, respectively) to flowers just opened (1.04 %, 4.23 % and 6.60 %, respectively). The content of dianthrones and quercetin glycosides then decreased (in unripe fruits 0.11 % and 0.08 %, respectively), whereas the amounts of hyperforin increased to 8.07 % in fruits. The content of I3,II8-biapigenin increased from 0.21 % in small buds to 1.04 % in buds just before opening and has then decreased gradually to a value of 0.02 % in fruits. Rutin was not detected in the samples.

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Dr. Daniela Tekel'ová

Department of Pharmacognosy and Botany Faculty of Pharmacy, Comenius University

Odbojárov 10

SK-83232 Bratislava

Slovak Republic

Email: tekelova@fpharm.uniba.sk

Phone: +421 7 55572065