J Reconstr Microsurg 2000; Volume 16(Number 8): 0613-0620
DOI: 10.1055/s-2000-9379
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel. +1(212)584-4662.

Effects of Fkbp-12 Ligands Following Tibial Nerve Injury in Rats

Devra B. Becker, John N. Jensen, Terence M. Myckatyn, Vaishali B. Doolabh, Daniel A. Hunter, Susan E. Mackinnon
  • Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Missouri
Further Information

Publication History

Publication Date:
31 December 2000 (online)

ABSTRACT

-The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury.