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Am J Perinatol 2000; Volume 17(Number 03): 113-120
DOI: 10.1055/s-2000-9293
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

HYPOXIC-ISCHEMIC ENCEPHALOPATHY

Robert C. Vannucci
  • Department of Pediatric Neurology, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey Pennsylvania
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Cerebral hypoxia-ischemia (asphyxia) occurring in the fetus and newborn infant is a major cause of acute mortality and chronic neurological disability in survivors. This review highlights many practical aspects of perinatal hypoxic-ischemic brain damage, including neuropathological features, obstetrical antecedents, and clinically important aspects of identification, management, and prognosis. Diagnostic techniques, including neuro-imaging, to diagnose hypoxic-ischemic encephalopathy also are discussed. A thorough knowledge of the clinical spectrum of perinatal hypoxic-ischemic encephalopathy should enable neonatologists to undertake appropriate management strategies and prognostic indicators.

KEYWORD

Asphyxia - brain - fetus - hypoxia-ischemia - perinatal

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