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Am J Perinatol 2000; Volume 17(Number 03): 159-162
DOI: 10.1055/s-2000-9279
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

VARIATIONS IN NEUTROPHIL COUNT IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME WHO SUBSEQUENTLY DEVELOPED CHRONIC LUNG DISEASE

David Kohelet1,4 , Eliana Arbel1,4 , Ami Ballin4 , Michael Goldberg3,4
  • 1Department of Neonatology, Edith Wolfson Medical Center, Holon
  • 2Department of Pediatric Hematology, Edith Wolfson Medical Center, Holon
  • 3Department of Neonatology, Assaf Harofeh Medical Center, Zerifin
  • 4Sackler School of Medicine, Tel Aviv University, Israel
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Publikationsdatum:
31. Dezember 2000 (online)

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ABSTRACT

Neutrophil counts were studied in 62 preterm infants receiving mechanical ventilation for neonatal respiratory distress syndrome (NRDS). Exploratory analysis indicated that the severity of NRDS, as demonstrated by fractional inspired oxygen (FiO2), mean airway pressure (MAP), arterial-alveolar PO2 ratio (a/APO2) and oxygenation index (OI), was correlated with percentage change of neutrophil counts during the first 5 days of life. Further analysis demonstrated that infants with NRDS who subsequently developed chronic lung disease (CLD) (n = 21) had statistically significant differences in variation of neutrophil counts when compared with the remainder (n = 41) without CLD (-35.0% ± 4.3 vs. -16.9% ± 5.8, p < 0.02). It is concluded that significant variations in neutrophil counts during the first 5 days of life may be found in infants with NRDS who subsequently develop CLD and that these changes may have predictive value regarding the development of CLD.

KEYWORD

CLD - neutrophil counts - preterm infant - RDS

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