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Synlett 2000; 2000(12): 1822-1824
DOI: 10.1055/s-2000-8676
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Synthesis of Constitutionally Unsymmetric 7-Membered Biaryl Lactones by Ni-Mediated Intramolecular Coupling

Gerhard Bringmann* , Jürgen Hinrichs, Petra Henschel, Karl Peters, Eva-Maria Peters
  • *Institut für Organische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany; Fax +49(931)8 88 47 55; E-mail: bringman@chemie.uni-wuerzburg.de
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Publikationsdatum:
31. Dezember 2000 (online)

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The synthesis of a new constitutionally unsymmetric, configurationally stable (since 7-membered) biaryl lactone is described. Among several `redox-neutral' and reductive coupling methods tested, only the Ni(0)-mediated intramolecular ring closure of suitably substituted dihalogen esters gave 7-membered biaryl lactones.

intramolecular biaryl coupling - nickel - lactones - bridged biaryls - axial chirality