Planta Med 2000; 66(3): 287-289
DOI: 10.1055/s-2000-8571
Original Paper
Georg Thieme Verlag Stuttgart · New York

Antiplatelet and Antithrombotic Effects of the Diterpene Spiramine Q from Spiraea japonica var. incisa

Zhiqiang Shen1,* , Zhihe Chen1,* , Ling Li1 , Weiya Lei1 , Xiaojiang Hao2
  • 1 Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, P. R. China
  • 2 Kunming Institute of Botany, The Chinese Academy of Sciences, P. R. China
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Spiramine Q, a diterpene, was isolated from a Chinese herbal plant Spiraea japonica var. incisa Yu. Born's and Wan HY's methods were used to investigate effects of spiramine Q on rabbit platelet aggregation and serotonin release, respectively. Its antithrombotic effect in mice was also evaluated by Myers' method. Spiramine Q selectively inhibited arachidonic acid-induced platelet aggregation in vitro or ex vivo, and decreased serotonin secretion from rabbit platelets. Spiramine Q (5 mg/kg) decreased the mouse mortality caused by injection of 80 mg/kg arachidonic acid in the tail vein. The results suggested that spiramine Q showed potent antiplatelet and antithrombotic activites.

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Shen Zhiqiang

Yunnan Pharmacological Laboratories of Natural Products Kunming Medical College, Kunming 650031

Yunnan Province

P. R. China

Email: szq2000@yahoo.com

Phone: +86-871-5316884