Planta Med 2000; 66(3): 291-294
DOI: 10.1055/s-2000-8568
Letter
Georg Thieme Verlag Stuttgart · New York

Diterpenoids from Euphorbia peplus

Judit Hohmann1,*, Ferenc Evanics2 , László Berta1 , Tibor Bartók3
  • 1 Department of Pharmacognosy, Albert Szent-Györgyi Medical University, Szeged, Hungary
  • 2 Department of Pharmaceutical Analysis, Albert Szent-Györgyi Medical University, Szeged, Hungary
  • 3 Cereal Research Non-Profit Company, Szeged, Hungary
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

Abstract

From a pro-inflammatory active extract of Euphorbia peplus, two new diterpene polyesters based on the pepluane and jatrophane skeletons were isolated, together with four known ingenane and jatrophane diterpenes. The structures were determined on the basis of extensive NMR studies. Ingenol 3-angelate, which was obtained for the first time from this plant, is an irritant toxin with high activity.

References

  • 1 Gotta  H,, Adolf  W,, Opfenkuch  H J,, Hecker  E.. On the active principle of the Euphorbiaceae. IX. Ingenane type diterpene esters from five Euphorbia species.  Zeitschrift für Naturforschung. 1984;;  39b 683-94
  • 2 Rizk  A M,, Hammouda  F M,, El-Missiry  M M,, Radwan  H M,, Evans  F J.. Biologically active diterpene esters from Euphorbia peplus.   Phytochemistry. 1985;;  24 1605-6
  • 3 Zayed  S MAD,, Farghlay  M,, Taha  H,, Gotta  H,, Hecker  E.. Dietary cancer risk conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae) I. Skin irritant and tumor-promoting ingenane-type diterpene esters in E. peplus, one of several herbaceous Euphorbia species contaminating fodder of livestock.  Journal of Cancer Research and Clinical Oncology. 1998;;  124 131-40
  • 4 Jakupovic  J,, Morgenstern  T,, Bittner  M,, Silva  M.. Diterpenes from Euphorbia peplus.   Phytochemistry. 1998;;  47 1601-9
  • 5 Hohmann  J,, Günther  G,, Vasas  A,, Kálmán  A,, Argay  Gy.. Isolation and structure revision of pepluane diterpenoids from Euphorbia peplus. .  Journal of Natural Products. 1999;;  62 107-9
  • 6 Hohmann  J,, Vasas  A,, Günther  G,, Dombi  Gy,, Blazsó  G,, Falkay  Gy et al.. Jatrophane diterpenoids from Euphorbia peplus. .  Phytochemistry. 1999;;  51 673-7
  • 7 Marco  J A,, Sanz-Cervera  J F,, Yuste  A.. Ingenane and lathyrane diterpenes from the latex of Euphorbia canariensis. .  Phytochemistry. 1997;;  45 563-70

Dr. Judit Hohmann

Department of Pharmacognosy Albert Szent-Györgyi Medical University

P.O. Box 121

6701 Szeged

Hungary

eMail: hohmann@pharma.szote.u-szeged.hu

Telefon: +36 62 426146