Planta Med 2000; 66(3): 277-279
DOI: 10.1055/s-2000-8558
Letter
Georg Thieme Verlag Stuttgart · New York

Coumarins and Carbazoles with Antiplasmodial Activity from Clausena harmandiana

Chavi Yenjai1 , Somkrit Sripontan2 , Prachack Sriprajun2 , Prasat Kittakoop3,*, Amnuay Jintasirikul3 , Morakot Tanticharoen3 , Yodhathai Thebtaranonth3, 4
  • 1 Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
  • 2 Junior Science Talent Project, Thailand
  • 3 National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok, Thailand
  • 4 Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Activity guided fractionation of extracts from Clausena harmandiana have led to the identification of four known compounds, heptaphylline (1), clausine K (2), dentatin (5), and clausarin (6). All these compounds, except clausine K (2), exhibited antiplasmodial activity against Plasmodium falciparum. While the new dimethylated derivative 4, derived from 2, showed no antiplasmodial activity, the monomethylated product 3 (clausine H) exhibited activity comparable to that observed for compounds 1 and 5.

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Dr. Prasat Kittakoop

National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency

73/1, Rama VI Road

Bangkok 10400

Thailand

Email: prasat@biotec.or.th

Phone: +66-2-6448107