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Semin Thromb Hemost 2000; Volume 26(Number 03): 297-304
DOI: 10.1055/s-2000-8097
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Homocysteine and Venous Thrombosis: Outline of a Vitamin Intervention Trial

HUUB. P.J. WILLEMS1 , MARTIN. DEN HEIJER2 , GERARD. M.J. BOS3
  • 1Department of Haematology, Leyenburg Hospital, The Hague
  • 2Department of Internal Medicine, Academical Hospital, Nijmegen
  • 3Department of Internal Medicine, Academical Hospital, Maastricht, The Netherlands
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

In the past years several case-control studies established the association of an elevated plasma homocysteine concentration and the risk of venous thromboembolism. It is still unclear if elevated homocysteine concentrations can cause venous thrombosis. The VITRO (VItamins and ThROmbosis) trial is the first multicenter, randomized, double-blind and placebo-controlled study to evaluate the effect of homocysteine-lowering therapy by means of 5 mg folic acid, 0.4 mg vitamin B 12 and 50 mg vitamin B6. The study is a secondary prevention trial in 600 patients who suffered from a first episode of idiopathic deep vein thrombosis (DVT) or pulmonary embolism (PE), or both. There will be 300 hyperhomocysteinemic and 300 normohomocysteinemic patients included, all with an objectivated venous thrombosis. The end point is recurrence of venous thrombosis.

KEYWORD

Homocysteine - hyperhomocysteinemia - venous thrombosis - vitamin treatment - multicenter trial

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