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Synlett 2000; 2000(11): 1631-1633
DOI: 10.1055/s-2000-7948
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Asymmetric Strecker Route Toward the Synthesis of the Corey Intermediate of Lactacystin

Seiji Iwama* , Wei-Guo Gao, Tetsuro Shinada, Yasufumi Ohfune
  • *Department of Material Science, Graduate School of Science, Osaka City University, Sugimoto, Osaka 558-8585, Japan; Fax +81-6-66 05-31 53; E-mail: ohfune@sci.osaka-cu.ac.jp
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Publication Date:
31 December 2000 (online)

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An efficient synthesis of Corey's precursor (2) of lactacystin has been accomplished by the use of asymmetric Strecker synthesis of α-acyloxyketone 4 having l-Phe as a chirality transferring group.

lactacystin - Corey's intermediate - asymmetric Strecker synthesis - α-acyloxyketone - amino nitrile

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