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Synlett 2000; 2000(11): 1694-1696
DOI: 10.1055/s-2000-7920
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Synthesis of a Vitamin B12 Derivative with a Dipyrrole Side Chain

Rui Fraga* , Reinhart Keese
  • *Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland; E-mail: reinhart.keese@ioc.unibe.ch
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Publication Date:
31 December 2000 (online)

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A four-step procedure for the preparation of 2,2-bis(6-N-pyrrylhexyl)-ethanol 6 in 31% yield is described. Esterification with hexamethyl cobyrate 7 leads to the dipyrrole derivative 8 in 74% isolated yield.

1-(6-bromohexyl)pyrrole - bis(6-pyrrol-1-ylhexyl)malonates - decarboxylation - hexamethyl-dicyano-cob(III)yrinate - hexamethyl-c-bis(6-pyrrol-1-ylhexyl)ethyl-dicyano-cob(III)yrinate

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