Download PDF
Laryngorhinootologie 2000; 79(10): 573-578
DOI: 10.1055/s-2000-7673
LARYNX
Georg Thieme Verlag Stuttgart · New York

Neuroendokrine Tumoren des Larynx (NETL)

 M. Hoff ,  B. Kramp
  • Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie Otto Körner der Universität Rostock (Direktor: Prof. Dr. med. H. W. Pau)
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Kasuistik: Ausgehend von einem Patienten mit einem atypischen Karzinoid wird eine umfassende Literaturrecherche durchgeführt. Hintergrund: Es wird insbesondere auf die Terminologie, histologische Differenzierung, Diagnostik und Therapie neuroendokriner Tumoren eingegangen. Schlussfolgerungen: Die Lokalisation dieser Tumoren im Larynx ist untypisch und relativ selten. Dennoch sollte sie wegen der möglichen malignen bis hochmalignen Verläufe der verschiedenen Subtypen als Differenzialdiagnose geläufig sein. Da sich die laryngeale Manifestation dieses neuroendokrinen Tumors (NET) klinisch different von entsprechenden Tumoren gastrointestinaler oder pulmonaler Lokalisation verhält, lassen sich Therapieschemata nicht ohne weiteres übertragen. Um so wichtiger erscheint es, diese Tumoridentität wissenschaftlich genauer zu untersuchen. Schwierigkeiten ergeben sich dabei aus den insgesamt sehr geringen Patientenzahlen, weshalb es das Anliegen dieser Arbeit ist, das bisherige Wissen zusammenzufassen und auf die Wichtigkeit der Publikation von Neuerkrankungen hinzuweisen.

Neuroendocrine Tumor of the Larynx (NETL) - An Uncommon Differential Diagnosis

Casuistry: The case of a patient with atypical carcinoid of the larynx is reported and literature about neuroendocrine tumors of the larynx (NETL) is reviewed. Background: Especially terminology, histological differentiation, diagnostics and therapy are discussed. Conclusions: Neuroendocrine tumors are rare and untypically located in the larynx. In spite of this they should to be known as an important differential diagnosis of a laryngeal neoplasia, because of possible malign or highly malign course. The typical localisation of neuroendocrine tumors (NET) are the gastrointestinal tract and the lung, but the clinical course differs from the one of laryngeal manifestation. This means diagnostics and therapy have to be adapted to this special disease. That's why it is important to explore the identity of these tumors scientifically. This is difficult because of the low rate of patients with this disease. The message of this report is the conclusion of the established and appeal for publications of new cases of NETL.

Schlüsselwörter:

Karzinoid - Larynx - Neuroendokrin - Paragangliom - Tumor

Key words:

Carcinoid - Larynx - Neuroendocrine - Paraganglioma - Tumor

Literatur

  • 1 Kleinsasser O. Revision of classification of laryngeal cancer, is it long overdue? (Proposals for an improved TN-classification.)  J Laryngol Otol. 1992;  106 197-204
    PubMedGoogle Scholar
  • 2 Kleinsasser O. Sarcomalike patterns in laryngeal carcinoma (pseudosarcoma, carcinosarcoma, spindle-cell-carcinoma, pleomorphic carcinoma [author's transl]).  Laryngo-Rhino-Otol. 1978;  57 225-234
    PubMedGoogle Scholar
  • 3 Meyer-Breitling E, Burkhardt A. Tumours of the larynx. 1. Aufl. Springer-Verlag 1988 80: 153
    Google Scholar
  • 04 Batsakis J G, Luna M A, el-Naggar A K. Nonsquamous carcinomas of the larynx.  Ann Otol Rhinol Laryngol. 1992;  101 1024-1026
    Google Scholar
  • 05 Lam K Y, Yuen A P. Cancer of the larynx in Hong Kong: a clinico-pathological study.  Eur J Surg Oncol. 1996;  22 166-170
    Google Scholar
  • 06 Herold G. Innere Medizin. Köln; 1996: 305-309
    Google Scholar
  • 07 Riede U N, Schaefer H E. Diffuses neuroendokrines System.  Allgemeine und Spezielle Pathologie. 4. Aufl. Thieme-Verlag 1995: 1011-1014
    Google Scholar
  • 08 Travis N D, Linnoila R I, Tsokos M G . et al .Neuroendocrine tumors of the lung with proposed criteria for large cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical and flowcytometric study of 35 cases. Amer J Surg Pathol 1991
    Google Scholar
  • 09 Gould V E, Lee I, Warren W H. Immunohistochemical Evaluation of Neuroendocrine Cells and Neoplasms of the Lung.  Path Res Pract. 1988;  183 200-213
    Google Scholar
  • 10 Delcore R, Friesen S R. Gastrointestinal neuroendocrine tumors.  J Amer Surg. 1994;  178 187-211
    PubMedGoogle Scholar
  • 11 Modlin I M, Sandor A. An analysis of 8305 cases of carcinoid tumors.  Cancer. 1997;  79 813-829
    CrossrefPubMedGoogle Scholar
  • 12 Öberg K. Biology, diagnosis and treatment of neuroendocrine tumors of the gastrointestinal tract.  Curr Opin Oncol. 1994;  4 441-451
    PubMedGoogle Scholar
  • 13 Perry R, Vinik A. Endocrine tumors of the gastrointestinal tract.  Ann Rev Med. 1996;  47 57-68
    CrossrefPubMedGoogle Scholar
  • 14 Moisa I I, Silver C E. Treatment of neuroendocrine neoplasms of the larynx.  J Oto-Rhino-Laryngol. 1991;  53 259-264
    PubMedGoogle Scholar
  • 15 Ferlito A . et al . A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment.  J Laryngol Otol. 1998;  112 827-834
    PubMedGoogle Scholar
  • 16 Ferlito A, Barnes L, Wenig B M. Identification, classification, treatment, and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases.  Ann Otol-Rhinol-Laryngol. 1994;  103 525-536
    PubMedGoogle Scholar
  • 17 Ferlito A, Friedmann I. Contribution of immunhistochemistry in the diagnosis of neuroendocrine neoplasms of the larynx.  J Oto-Rhino-Laryngol. 1991;  53 235-244
    PubMedGoogle Scholar
  • 18 Ferlito A, Rosai J. Terminology and classification of neuroendocrine neoplasms of the larynx.  J Oto-Rhino-Laryngol. 1991;  53 185-187
    PubMedGoogle Scholar
  • 19 Barnes L. Paraganglioma of the larynx. A critical review of the literature.  J Oto-Rhino-Laryngol. 1991;  53 220-234
    PubMedGoogle Scholar
  • 20 Gnepp D R. Small cell neuroendocrine carcinoma of the larynx. A critical review of the literature.  J Oto-Rhino-Laryngol. 1991;  53 210-219
    PubMedGoogle Scholar
  • 21 Woodruff J M, Senie R T. Atypical carcinoid tumor of the larynx. A critical review of the literature.  J Oto-Rhino-Laryngol. 1991;  53 194-209
    PubMedGoogle Scholar
  • 22 Martinez-Madrigal F, Bosq J, Micheau C, Nivet P, Luboinski B. Paragangliomas of the head and neck. Immunohistochemical analysis of 16 cases in comparison with neuroendocrine carcinomas.  Pathol Res Pract. 1991;  187 814-823
    PubMedGoogle Scholar
  • 23 Salim S A, Milroy C, Rode J, Corrin B, Hamid Q. Immunocytochemical characterization of neuroendocrine tumours of the larynx.  Histopathology. 1993;  23 69-73
    PubMedGoogle Scholar
  • 24 Blok P H, Manni J J, van den Broek P, van Haelst U J, Slooff J L. Carcinoid of the larynx: a report of three cases and a review of the literature.  Laryngoscope. 1985;  95 715-719
    PubMedGoogle Scholar
  • 25 Woodruff J M, Huvos A G, Erlandson R A, Shah J P, Gerold F P. Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma.  Amer J Surg Pathol. 1985;  9 771-790
    PubMedGoogle Scholar
  • 26 Dieler R, Dammrich J. Immunohistochemical and fine structural characterization of primary carcinoid tumors of the larynx.  Europ Arch Otorhinolaryngol. 1995;  252 229-235
    PubMedGoogle Scholar
  • 27 Dellagi K, Jaubert F, Micheau C, Brasnu D, Laccoureye H. Carcinoid of the larynx. Well-differentiated neuroendocrine carcinoma. Apropos of 4 cases.  Ann Pathol. 1989;  9 284-288
    PubMedGoogle Scholar
  • 28 Ereno C, Lopez J I, Sanchez J M. Atypical carcinoid of larynx: presentation with scalp metastases.  J Laryngol Otol. 1997;  111 89-91
    PubMedGoogle Scholar
  • 29 Batsakis J G, el-Naggar A K, Luna M A. Neuroendocrine tumors of larynx.  Ann Otol-Rhinol-Laryngol. 1992;  101 710-714
    PubMedGoogle Scholar
  • 30 Kau R, Arnold W. Somatostatin receptor scintigraphy and therapy of neuroendocrine (APUD) tumors of the head and neck.  Acta Otolaryngol. 1996;  116 345
    PubMedGoogle Scholar
  • 31 Moertel C G. Treatment of the carcinoid tumor and the malignant carcinoid syndrome.  J Clin Oncol. 1983;  1 727-740
    PubMedGoogle Scholar
  • 32 Moertel C G, Rubin J, Kvols L K. Therapy of metastatic carcinoid tumor and the malignant carcinoid syndrome with recombinant leukocyte A interferon.  J Clin Oncol. 1989;  7 865-868
    PubMedGoogle Scholar

Dr. med. Michael Hoff

HNO-Universitätsklinik Otto Körner

Doberaner Straße 137 - 139 18057 Rostock