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Synlett 2000; 2000(10): 1429-1432
DOI: 10.1055/s-2000-7649
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Synthesis of N-Protected Arylglycine Derivatives via Hydroxyl-Directed, TiCl4-Promoted Friedel-Crafts Reaction of Phenols with N-Tosyl Imino Ester

Yong-Jun Chen* , Cheng-Sheng Ge, Dong Wang
  • *Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P.R. China
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Publication Date:
31 December 2000 (online)

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N-protected arylglycine derivatives were obtained via TiCl4-promoted, hydroxyl-directed Friedel-Crafts reaction of various phenols with N-tosyl imino ester in good yields.

Friedel-Crafts reaction - arylglycine - N-tosyl imino ester - TiCl4

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