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Synlett 2000; 2000(9): 1261-1264
DOI: 10.1055/s-2000-7134
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New Efficient Catalysts for the Palladium-Catalyzed Coupling of Alkynes to Enynes

Ulrich Lücking* , Andreas Pfaltz
  • *Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany
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Publication Date:
31 December 2000 (online)

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Palladium complexes with phosphinooxazoline ligands are very efficient catalysts for the coupling of alkynes to enynes. The catalyst system could be employed in solvent-free reactions and provided an efficient means for the regiocontrol of cross-coupling reactions between mono- and disubstituted alkynes. Using enantiomerically pure ligands, kinetic resolution of racemic propargylic alcohols to optically active enynes was achieved.

alkynes - enynes - palladium - phosphinooxazoline ligands - alkyne coupling - kinetic resolution