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Synlett 2000; 2000(8): 1169-1171
DOI: 10.1055/s-2000-6752
DOI: 10.1055/s-2000-6752
letter
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Mild and Efficient Dehydration of Oximes to Nitriles Mediated by the Burgess Reagent
Further Information
Publication History
Publication Date:
31 December 2000 (online)
Both aliphatic and aromatic aldoximes undergo dehydration to the corresponding nitriles in excellent yields by simply heating the oximes in THF with 1.5 equivalents of the Burgess reagent (methyl-N-(triethylammonium-sulfonyl)carbamate). The reaction also works well using the PEG-supported Burgess reagent and thus has considerable potential for the parallel synthesis of cyano-containing compound libraries.
Burgess reagent - oxime - nitrile - dehydration - PEG-support