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Synlett 2000; 2000(8): 1107-1110
DOI: 10.1055/s-2000-6736
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Regio- and Enantioselective Siloxybutylation at the More Hindered α-Site of Unsymmetrical Ketone Using Chiral Aluminum Trisnaphthoxide

Susumu Saito* , Masakazu Nakadai, Hisashi Yamamoto
  • *Graduate School of Engineering, Nagoya University, CREST, Japan Science and Technology Corporation (JST), Chikusa, Nagoya 464-8603, Japan
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Publication Date:
31 December 2000 (online)

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A regio- and enantioselective siloxybutylation at the more hindered α-site of unsymmetrical dialkyl ketones was achieved to give a quarternary carbon center by the combined use of the chiral aluminum trisnaphthoxide (R)-ATBN and a base.

alkylations - aluminum - asymmetric synthesis - ketones