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Synlett 2000; 2000(6): 0809-0810
DOI: 10.1055/s-2000-6727
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Selective N-Methylation of Pyrazolone with Methanol by Use of ZrO2 Catalyst in the Liquid Phase

Sumio Shinoda* , Satoru Shima, Tetsu Yamakawa
  • *Institute of Industrial Science, The University of Tokyo, 7-22-1 Roppongi, Minato-ku, Tokyo 106-8558, Japan; Fax +81-03-3402-6350; E-mail: yamakawa@iis.u-tokyo-ac.jp
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Publication Date:
31 December 2000 (online)

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Selective methylation of pyrazolone to 1-methylpyrazolone was investigated with ZrO2, which is a representative metal oxide with amphoteric character. The high selectivity up to ∼ 77% was obtained at 503 K. Mechanism is proposed in view of weak acidic-moderately basic pair sites of ZrO2.

pyrazolone - selective methylation - methanol - metal oxide catalyst

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