Synlett 2000; 2000(6): 0856-0858
DOI: 10.1055/s-2000-6725
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A Palladium-Catalyzed Biaryl Coupling of Arylboronic Acids in Aqueous Media Using A Gluconamide-Substituted Triphenylphosphine (GLCAphos) Ligand

Masato Ueda* , Masato Nishimura, Norio Miyaura
  • *Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan; Fax +81-11-706-6561; E-mail: miyaura@org-mc.eng.hokudai.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

A water-soluble phosphine ligand, N-(4-diphenyl-phosphino)phenylmethyl gluconamide (GLCAphos), was newly synthesized to perform the palladium-catalyzed biaryl coupling of arylboronic acids in a single aqueous media. The catalyst prepared from GLCAphos revealed higher activity than that synthesized from Ph2P(m-C6H4SO3Na) or P(m-C6H4SO3Na)3 for various haloarenes.