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Synlett 2000; 2000(6): 0829-0831
DOI: 10.1055/s-2000-6718
DOI: 10.1055/s-2000-6718
letter
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A Convenient Synthesis of Heteroaryl Benzoic Acids via Suzuki Reaction
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synlett/200006/lookinside/thumbnails/10.1055-s-2000-6718-1.jpg)
An one step approach to heteroaryl benzoic acids from readily accessible heteroaryl halides and carboxybenzene boronic acids is described. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous acetonitrile. The scope and limitations of the reaction are discussed.
biaryls - carboxylic acids - cross-coupling - heteroaryl halides - palladium