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Synlett 2000; 2000(6): 0847-0849
DOI: 10.1055/s-2000-6712
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Fluorous Biphase Catalytic Friedel-Crafts Acylation: Ytterbium Tris(Perfluoroalkanesulfonyl)methide Catalysts

Anthony G. M. Barrett* , D. Christopher Braddock, David Catterick, David Chadwick, Julian P. Henschke, R. Murray McKinnell
  • *Departments of Chemistry and Chemical Engineering, Imperial College, South Kensington, London SW4 2AY, UK; E-mail: agmb@ic.ac.uk
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Publication History

Publication Date:
31 December 2000 (online)

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Ytterbium(III) tris(perfluoroalkanesulfonyl)methides were found to be effective catalysts (10 mol%) for the Friedel-Crafts acylation of arenes with acid anhydrides. In addition, with sufficient fluorous content in the ytterbium complex, the reactions could be run under a fluorous biphase regime where the catalyst is recycled and re-used by extraction of the spent acylation reaction mixture with perfluoromethyldecalin.

acylation - fluorous phase - catalysis - methide - ytterbium