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Synlett 2000; 2000(6): 0868-0871
DOI: 10.1055/s-2000-6704
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A Highly Chemoselective Protection and Activation of Primary Amines in Polyamine

Alain Favre-Réguillon* , Fabienne Segat-Dioury, Lalou Nait-Bouda, Camelia Cosma, Jean-Michel Siaugue, Jacques Foos, Alain Guy
  • *Laboratoire de Chimie Organique, ESA CNRS 7084, Conservatoire National des Arts et Métiers, 292, rue St Martin, 75003 Paris, France; Fax (33) 1 42 71 05 34; E-mail: guy@cnam.fr
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Publication Date:
31 December 2000 (online)

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Functionalization of polyamines containing both primary and secondary amine moieties could be achieved with the use of 2-nitrobenzenesulfonyl chloride. In the presence of a secondary amine, the primary amine groups are selectively transformed into the corresponding N-sulfonyl derivatives.

amines - protecting groups - sulfonamides - chemoselectivity

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