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Synlett 2000; 2000(6): 0874-0876
DOI: 10.1055/s-2000-6703
DOI: 10.1055/s-2000-6703
letter
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Straightforward Access to [6]Metacyclophene-based Enynes by an Inter-Intramolecular Tandem Etherification through a One-Pot Double SNAr Reaction
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Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synlett/200006/lookinside/thumbnails/10.1055-s-2000-6703-1.jpg)
The first application in the enediyne area of an inter-intramolecular tandem one-pot double SNAr reaction is demonstrated towards the synthesis of new bi- and tricyclic enediynes 1 and 17, respectively. These polyunsaturated macrocycles are very stable and are not prone to rearrange to a diradical species via a Bergman cycloaromatization. The 1,3-substitution pattern on the aromatic ring could impede this thermal process from occurring.
macrocyclic enediynes - macrocyclization - SNAr reaction