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Synlett 2000; 2000(6): 0896-0898
DOI: 10.1055/s-2000-6701
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A One-Step Synthesis of Aminosuccinyl Peptides

Nazar Flaih* , Caroline Gadjou, Olivier Lafont, Hervé Galons
  • *Laboratoire de Chimie Organique, Faculté de Pharmacie, 4, avenue de l'Observatoire, 75270 Paris Cedex 06, France; Fax +33 (0) 143290592; E-mail: galons@pharmacie.univ-paris5.fr
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Publication Date:
31 December 2000 (online)

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Aminosuccinyl peptides were obtained by acylation of α-amino esters with tert-butyloxycarbonyl-l- and d-aspartic acids in the presence of N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide and N-hydroxybenzotriazole.

acylation - amino acids - cyclizations - heterocycles - peptides