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Synlett 2000; 2000(7): 1046-1048
DOI: 10.1055/s-2000-6680
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Facile Synthesis of 3,4-Dihydroxyprolines as an Application of the l-Threonine Aldolase-Catalyzed Aldol Reaction

Mikio Fujii* , Tsuyoshi Miura, Tetsuya Kajimoto, Yoshiteru Ida
  • *School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Fax +81-3-37 84-81 91; E-mail: ida@pharm.showa-u.ac.jp
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Publication Date:
31 December 2000 (online)

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A new facile synthesis of 3,4-dihydroxyprolines was attained by taking advantage of the l-threonine aldolase, which catalyzes the aldol condensation reaction of aldehydes with glycine affording β-hydroxy-α-l-amino acids.

3,4-dihydroxyproline - l-threonine aldolase - aldol reactions - α-hydroxy-β-l-amino acids - enzymes