Download PDF
Synlett 2000; 2000(4): 559
DOI: 10.1055/s-2000-6578
synlett spotlight
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Methyl N-(triethylammonium-sulfonyl)carbamate: "Burgess Reagent"

Svenja Burckhardt*
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download Permissions and Reprints All articles of this category

Methyl N-(triethylammoniumsulfonyl)carbamate 1, also known as Burgess reagent, is a powerful dehydrating agent. Amongst other transformations it has been used to prepare isocyanides, nitriles, and nitrile oxides from formamides, primary amides and nitroalkanes respectively. In recent years its most notable application has been in the cyclodehydration of hydroxy amides and thioamides to afford the corresponding heterocycles.

      >