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Synlett 2000; 2000(4): 463-466
DOI: 10.1055/s-2000-6573
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A Synthesis of Cryptophycin 4 Using a Planar Chiral Molybdenum Cationic Complex

John A. Christopher* , Philip J. Kocienski, Alexander Kuhl, Richard Bell
  • *Department of Chemistry, Glasgow University, Glasgow, UK G12 8QQ; Fax +44 (1 41) 3 30 68 67; E-mail: p.kocienski@chem.gla.ac.uk
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Publication Date:
31 December 2000 (online)

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A synthesis of cytotoxic agent Cryptophycin 4 features a new approach to (5S,6R)-5-hydroxy-6-methyl-8-phenyl-(2E,7E)-dienoic acid in which the anti stereochemistry between two stereogenic centres is secured by addition of a 1,3-dioxan-4-ylcopper(I) reagent to a planar chiral molybdenum cationic complex.

antitumour - η 3-allyl cationic complex - molybdenum - Copper - planar chiral