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Synlett 2000; 2000(3): 427
DOI: 10.1055/s-2000-6546
DOI: 10.1055/s-2000-6546
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Chlorosulfonyl Isocyanate
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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Chlorosulfonyl isocyanate (CSI), is known as the strongest biselectrophile. It is very useful in many synthetic transformations and in the synthesis of various heterocyclic systems.
CSI presents two sites of attack by nucleophiles: at the SO2 group and at the C=O function leading then, to N-sulfonylisocyanate and N-chlorosulfonyl derivatives, respectively, which can be easily functionalized by reaction with water, alcohol or amine. Furthermore, cycloaddition reactions to the C=N double bond of the isocyanate function can also occur.