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Synlett 2000; 2000(3): 345-346
DOI: 10.1055/s-2000-6525
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Preparation of New Magnesiated Functionalized Imidazoles and Antipyrines via an Iodine-Magnesium Exchange

Florian Dehmel* , Mohamed Abarbri, Paul Knochel
  • *Institut für Organische Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Building F, D-81377 München, Germany; Fax int. +89-21 80-76 80; E-mail: Paul.Knochel@cup.uni-muenchen.de
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Publication Date:
31 December 2000 (online)

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The iodine-magnesium exchange using i-PrMgBr allows the preparation of magnesiated 3-pyrazolin-5-ones (antipyrines) and functionalized imidazoles which after reaction with various electrophiles afford polyfunctional 5-membered heterocycles.

imidazoles - antipyrines - Grignard reagents - functionalized organometallics - iodine-magnesium exchange