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Synlett 2000; 2000(3): 315-318
DOI: 10.1055/s-2000-6518
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A Stereoselective Synthesis of the C13-C19 Fragment of Sanglifehrin A

Philip Hall* , Jvan Brun, Donatienne Denni, Rainer Metternich
  • *Novartis Pharma AG, Research, CH-4002 Basel, Switzerland; E-mail: rainer.metternich@pharma.novartis.com
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Publication Date:
31 December 2000 (online)

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A short, stereoselective route to the C13-C19 fragment of the immunosuppressant sanglifehrin A 1, is presented. The key step involves a highly diastereoselective boron aldol reaction between β-ketoimide 11 and triisopropylsilyl propargyl aldehyde 21c.

sanglifehrin A - β-ketoimide - methyl ester - tellurium