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Synlett 2000; 2000(3): 409-411
DOI: 10.1055/s-2000-6516
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Synthesis of Amino Alcohol Derivatives from (l)-Pyroglutamic Acid on Solid-Phase

Janine Cossy* , Ludovic Tresnard, Domingo Gomez Pardo
  • *Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France; Fax 33-1-40-79-46-60; E-mail: janine.cossy@espci.fr
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Publikationsdatum:
31. Dezember 2000 (online)

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A procedure for the solid phase synthesis of optically active substituted N-tosyl amines from the corresponding N-tosyl lactams has been developed. A variety of N-tosyl amines were synthesized by ring-opening of N-tosyl lactams by various nucleophiles such as alkoxides, amines or Grignard reagents.

(l)-pyroglutamic acid - ring opening - solid-phase synthesis - sulfonamides - Ellman's DHP resin