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Synlett 2000; 2000(1): 116-118
DOI: 10.1055/s-2000-6472
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A New Facile Method for the Synthesis of 4-Dialkylaminopyridine Derivatives by High-Pressure-Promoted Amination of 4-Chloropyridine

Hiyoshizo Kotsuki* , Hiromitsu Sakai, Toshio Shinohara
  • *Laboratory of Natural Product Synthesis, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan; Fax + 81-88-844-8360; E-mail: kotsuki@cc.kochi-u.ac.jp
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Publication Date:
31 December 2000 (online)

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A new method for synthesizing 4-(di)alkylaminopyridine derivatives in high yield was established by the high-pressure-promoted nucleophilic aromatic substitution of 4-chloropyridine with various primary/secondary amines.

DMAP - 4-chloropyridine - SNAr - high pressure