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Synlett 2000; 2000(1): 152-158
DOI: 10.1055/s-2000-6465
new tools in synthesis
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Covalent Scavengers for Primary and Secondary Amines

John C. Hodges*
  • *Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, Ann Arbor, MI 48105, USA; Fax (734)622-3107; E-mail: Jack.Hodges@wl.com
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Publication History

Publication Date:
31 December 2000 (online)

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Covalent scavenging strategies which rely upon the chemical reactivity of primary and secondary amines have found application in the separation of amine starting materials from combinatorial synthesis products. The use of solid-supported scavengers, sequestration enabling reagents, and the technique of impurity annihilation all allow the removal of structurally diverse amines by procedures that are easily carried out in parallel and are amenable to automation.

amines - automated synthesis - combinatorial chemistry - parallel purification - polymers

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