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Synthesis 2000; 2000(9): 1219-1222
DOI: 10.1055/s-2000-6407
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Hypervalent Iodine in Synthesis 53: Synthesis of 2,4-Disubstituted and 2,4,5-Trisubstituted 1,3-Selenazoles

Peng-Fei Zhang* , Zhen-Chu Chen
  • *Department of Chemistry, Zhejiang University (XiXi Campus), Hangzhou, Zhejiang 310028, P. R. China; E-mail: zhenchuc@mail.HZ.Zj.CN
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Publication Date:
31 December 2000 (online)

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α-Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene, followed by treatment with primary selenoamides provides a convenient method of synthesis of selenazoles without the use of lachrymatory and toxic α-haloketones. The synthetic method is simple, mild and the yields are higher.

α-tosyloxylation - selenium - primary selenoamides - [hydroxy(tosyloxy)iodo]benzene (HTIB) - cyclization - 2,4-disubstituted - 2,4,5-trisubstituted 1,3-selenazoles - heterocycles