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Synthesis 2000; 2000(5): 646-650
DOI: 10.1055/s-2000-6389
short paper
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Cobalt(II) Chloride-Catalyzed Chemoselective Sodium Borohydride Reduction of Azides in Water

Francesco Fringuelli* , Ferdinando Pizzo, Luigi Vaccaro
  • *Università di Perugia, Dipartimento di Chimica, Via Elce di Sotto, 8-06123 Perugia, Italy; Fax + 39(075)5 85 55 60
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Publication Date:
31 December 2000 (online)

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Reduction of azides to amines and amides was carried out with NaBH4/CoCl2 · 6 H2O in sole water at 25 °C under catalytic heterogeneous conditions. A broad spectrum of azides was reduced in a short time, chemoselectively in high yield and purity.

azide - reduction - cobalt(II) chloride - sodium borohydride

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