Int J Sports Med 2000; 21(5): 338-343
DOI: 10.1055/s-2000-3781
Physiology and Biochemistry
Georg Thieme Verlag Stuttgart · New York

The Effects of Exercise Training Intensification on Glucose Disposal in Elite Cyclists

J. Manetta,  J. F. Brun,  J. Mercier,  C. Prefaut
  • Service Central de Physiologie Clinique: Centre d'Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires (CERAMM), Lapeyronie Hospital, Montpellier, France
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

To assess the effect of training on glucose disposal, we performed a longitudinal study of 11 elite cyclists before and after 4 months of intensive training compared to 11 sedentary subjects. Insulin sensitivity (SI) and glucose effectiveness (Sg) were measured using Bergman's minimal model. Sg includes basal insulin effectiveness (BIE) and a parameter termed glucose effectiveness at zero insulin (GEZI). After overnight fasting glucose was administered intravenously (0.5 g × kg-1, 30 % solution given over 3 min), and insulin (0.02 U × kg-1, 1 - 2 U) was injected immediately after 19 min. Sg, SI and BIE, were significantly higher in elite cyclists both before and after training than in sedentary subjects (P < 0.01). However, the non-insulin-dependent component of Sg (GEZI) was higher only after the intensive training in the cyclists (3.31 ± 0.67 % × min-1) than in sedentary subjects (1.7 ± 0.2 % × min-1, P < 0.02). We conclude that insulin sensitivity (SI) and glucose effectiveness (Sg) are higher in elite cyclists than in sedentary subjects and that these high and almost optimal values are not further improved by additional training. However, the improvement in GEZI, as reflected by the difference between post-training GEZI and sedentary control values, raises the possibility of an increase of the non-insulin-mediated mobilization of glucose transporters.

References

  • 1 Astrand P O, Rodahl K. Physiological basis of exercise. Textbook of work physiology. 3rd ed. New York; MacGraw Hill 1986
  • 2 Bergman R N, Ider Y Z, Bowden C R, Cobelli C. Quantitative estimation of insulin sensitivity.  Am J Physiol. 1979;  236 E667-E677
  • 3 Bergman R N, Finegood D T, Adler M. Assessment of insulin sensitivity in vivo. .  Endocr Rev. 1985;  6 45-86
  • 4 Bouix O, Brun J F, Orsetti A. The magnitude, the kinetics and the metabolic efficiency of first-phase insulin response to intravenous glucose are related.  Horm Metab Res. 1993;  25 312-316
  • 5 Brun J F, Boegner C, Orsetti A. Le minimal model: un nouvel outil pour l'etude des hypoglycémies du sportif.  Sci Sports. 1994;  9 47-49
  • 6 Brun J F, Guintrand-Hugret R, Boegner C, Bouix O, Orsetti A. Influence of short submaximal exercise on parameters of glucose assimilation analyzed with minimal model.  Metabolism. 1995;  44 833-840
  • 7 Brun J F, Bouix O, Monnier J F, Blanchon P, Jourdan N, Baccara M T, Fedou C, Orsetti A. Increased insulin sensitivity and basal insulin effectiveness in postprandial reactive hypoglycaemia.  Acta Diabetologica. 1996;  33 1-6
  • 8 Brooks G A, Mercier J. Balance of carbohydrate and lipid during exercise: the 'crossover' concept.  J Appl Physiol. 1994;  76 2253-2261
  • 9 Douen A G, Ramlal T, Rastogi S. Exercise induces recruitment of the insulin-responsive glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.  J Biol Chem. 1990;  265 13427-13430
  • 10 Engfred K, Kjaer M, Secher N H, Friedman D B. Hypoxia and training-induced adaptation of hormonal responses to exercise in humans.  Eur J Appl Physiol. 1990;  68 303-309
  • 11 Finegood D T, Tzur D. Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal model method.  Am J Physiol. 1996;  271 E485-E495
  • 12 Houmard J A, Egan P C, Neufer P D, Friedeman J E, Wheeler W S, Israel R G. Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men.  Am J Physiol (Endocrinol Metab. 24). 1991;  261 E437-E443
  • 13 Khan S E, Bergman R N, Schwartz M W, Taborsky G J, Porte D Jr. Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans.  Am J Physiol. 1992;  262 E518-E523
  • 14 Klip A, Marette A. Acute and chronic signals controlling glucose transport in skeletal muscle.  J Cell Biochem. 1992;  48 51-60
  • 15 Koivisto V A, Yki-Järvinen A, DeFronzo R. Physical training and insulin sensitivity.  Diabetes Metab Rev. 1986;  1 445-481
  • 16 Lukaski H C, Johnson P E, Bolonchuch W W, Lykken V. Assessment of fat-free mass using bioelectrical impedance measurements of the human body.  Am J Clin Nutr. 1985;  41 810-817
  • 17 Manetta J, Khaled S, Bouix D, Krechiem K, Brun J F, Orsetti A. Evaluation d'un questionnaire alimentaire court par comparaison avec un entretien diététique chez des sujets sportifs et sédentaires.  Sci Sport. 1997;  12 210-213
  • 18 Matthews D R, Hosker J P, Rudenski A S, Naylor B A, Treacher D F, Turner R C. Homeostasis model assessment: insulin and beta-cell function from fasting plasma glucose and insulin concentrations in man.  Diabetologia. 1985;  28 412-419
  • 19 Mikines K J, Sonne B, Farrel P A. Effect of physial exercise on sensitivity and responsiveness to insulin in humans.  Am J Physiol. 1988;  254 E248-E259
  • 20 Monnier J F, Raynaud E, Brun J F, Orsetti A. Evaluation de la répétabilité moyenne d'une technique d'impédancemétrie appliquée à la détermination de la composition corporelle.  Sci Sports. 1997;  12 208-209
  • 21 Ni T C, Ader M, Bergman R N. Reassessment of glucose effectiveness and insulin sensitivity from minimal model analysis. A theoretical evaluation of the single compartment glucose distribution assumption.  Diabetes. 1997;  46 1813-1821
  • 22 Oja P, Laukkanen R M, Kukkonen-Harjula T K, Vuori I M. Training effect of cross country skiing and running on maximal aerobic cycle performance and blood lipids.  Eur J Appl Physiol. 1991;  62 400-404
  • 23 Orsetti A, Brun J F, Galtier-Dereure F. Effect de l'obésité sur l'insulino-résistance des DNIDs et des sujets non diabétiques. ALFEDIAM Paris; Diabete & Metabolisme 1996
  • 24 Ploug T, StallKnecht B M, Pedersen O, Khan B B, Ohkuwa T, Vinten J, Galbo H. Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle.  Am J Physiol. 1990;  259 E778-E786
  • 25 Quon M J, Cochran C, Taylor S I, Eastman R C. Non-insulin-mediated glucose disappearance in subjects with IDDM: discordance between experimental results and minimal-model analysis.  Diabetes. 1994;  43 890-896
  • 26 Rodnick K J, Haskell W L, Swislocki A. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilisation in normal humans.  Am J Physiol. 1987;  253 E 489-E 495
  • 27 Rosenthal M, Haskell W L, Solomon R, Widstrom A, Reaven G M. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilisation in normal humans.  Diabetes. 1983;  32 408-411
  • 28 Ruderman N B, Balton T, Zorzano A, Goodman M. The post-exercise state: altered effects of insulin on skeletal muscle and their physiologic relevance.  Diabetes Metab Rev. 1986;  1 425-444
  • 29 Seals D R, Hagberg J M, Allen W K, Hurley B F, Dalsky G P, Ehsani A, Hollozy J O. Glucose tolerance in young and older athletes and sedentary men.  J Appl Physiol. 1984;  56 1521-1525
  • 30 Steil G M, Bergman R M. Reduced sampling for the minimal model estimate of insulin sensitivity from the modified and standard frequency sampled IVGTT.  Diabetes. 1991;  40 38 A
  • 31 Tamburrano G, Leonetti F, Sbraccia P, Giaccari A, Locuratolo N, Lala A. Increased insulin sensitivity in patients with idiopathic reactive hypoglycemia.  J Clin Endocrinol Metab. 1989;  69 885-891
  • 32 Tokuyama K, Higaki Y, Fujitani J, Kiyonaga A, Tanaka H, Shindo M, Fukushima M, Nakal Y, Imura H, Nagata I. Intravenous glucose tolerance test-derived glucose effectiveness in physically trained humans.  Am J Physiol. 1993;  265 E298-E303
  • 33 Walton C, Godland I F, Proudler J, Felton C V, Wynn V. Effect of body mass index and fat distribution on insulin sensitivity, secretion in nonobese healthy men.  J Clin Endocr Metab. 1990;  75 170-175
  • 34 Wahlund H. Determination of physical working capacity.  Acta Med Scand. 1948;  215 1-78
  • 35 Ward G M, Weber K M, Walters I M, Altken P M, Lee B, Best J D, Boston R C, Alford F P. A modified minimal model analysis of insulin sensitivity and glucose-mediated disposal in insulin-dependent diabetes.  Metabolism. 1991;  40 4-9
  • 36 Yang Y J, Youn J A, Bergman R N. Modified protocols to improve insulin sensitivity estimation using the minimal model.  Am J Physiol. 1987;  253 E595-E602

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