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Planta Med 2000; 66(3): 279-281
DOI: 10.1055/s-2000-14894
Letter

Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Coumarins from Decatropis bicolor on TPA Ear Mice Model

Aída N. García-Argáez1 , Teresa O. Ramírez Apan2 , Hortensia Parra Delgado2 , Guillermo Velázquez2 , Mariano Martínez-Vázquez2
  • 1 Laboratorio de Química, Facultad de Ciencias, Universidad Nacional Autónoma de México, México
  • 2 Instituto de Química, Universidad Nacional Autónoma de México, México
  • 3 National Research Institute of Chinese Medicine, Taipei City, Taiwan, R.O.C.
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Publication History

June 16, 1999

July 11, 1999

Publication Date:
31 December 2000 (online)

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Abstract

From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1 - 6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.