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Planta Med 2000; 66(3): 279-281
DOI: 10.1055/s-2000-14894
DOI: 10.1055/s-2000-14894
Letter
Georg Thieme Verlag Stuttgart · New York
Anti-Inflammatory Activity of Coumarins from Decatropis bicolor on TPA Ear Mice Model
Further Information
Publication History
June 16, 1999
July 11, 1999
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200003/lookinside/thumbnails/10.1055-s-2000-14894-1.jpg)
Abstract
From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1 - 6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.