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Am J Perinatol 2000; 17(7): 367-370
DOI: 10.1055/s-2000-13444
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

MATERNAL SICKLE CELL TRAIT AND FETAL HYPOXIA

Shabih Manzar
  • Department of Neonatology, King Faisal University & King Fahd University Hospital, Al-Khobar, Saudi Arabia
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Patients with sickle cell trait (SCT) usually run a benign course. But they may develop vaso-occlusive crisis, which may lead to hypoxia. During these episodes, pregnant women with SCT may effect the developing fetus. This report describes an interesting finding of subtle degree of fetal hypoxia associated with maternal SCT. Twenty mothers with SCT were compared with 20 controls for the amount of circulating nucleated red blood cells (NRBC) and marker of fetal hypoxia at birth. Elevated number of circulating NRBC were noted in the cord blood of neonates born to mother with SCT as compared with controls, suggesting evidence of intrauterine fetal hypoxia. A larger prospective study is needed to elaborate further on this association.

KEYWORD

Fetal hypoxia - sickle cell trait - nucleated red blood cell (NRBC) count

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