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Semin Thromb Hemost 2000; 26(5): 571-588
DOI: 10.1055/s-2000-13214
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

LPS and Cytokine-Activated Endothelium

Angelika Bierhaus, Jiang Chen, Birgit Liliensiek, Peter P. Nawroth
  • Department of Medicine IV, Section of Vascular Medicine, University of Tübingen, Tübingen, Germany
Further Information

Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Endothelial cells coordinate the recruitment of inflammatory cells to sites of vascular injury. Endothelial cells produce and release cytokines and growth factors serving as communication signals to leukocytes as well as with organs and tissues. In addition, endothelial cells respond to inflammatory stimuli such as lipopolysaccharides (endotoxin, LPS), cytokines, or ligation of CD40. Functional changes in response to inflammatory stimuli are mediated by induction of signaling cascades leading to activation of transcription factors and alterations in endothelial gene expression. This article summarizes the current knowledge of molecular events resulting in cytokine-mediated endothelial dysfunction.

KEYWORD

NF-κB - inflammation - TNF-α - CD40 - apoptosis

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