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Planta Med 2000; 66(2): 169-171
DOI: 10.1055/s-2000-11132
DOI: 10.1055/s-2000-11132
Letters
Georg Thieme Verlag Stuttgart · New York
Isolation of 10-Hydroxycoronaridine from Tabernaemontana penduliflora and its Estrogen-Like Activity
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200002/lookinside/thumbnails/10.1055-s-2000-11132-1.jpg)
Abstract
The methanol extract of Tabernaemontana penduliflora was found to appreciably inhibit [3 H]-estradiol binding to estrogen receptors. Activity-guided fractionation led to the isolation of two known alkaloids, 10-hydroxycoronaridine (1) and its 10-O-methyl ether, voacangine (2). These alkaloids together with other related alkaloids were tested for their estrogenic activities. Among these molecules, 1 was found to be the most potent estrogen agonist and is distinctly more active than genistein.
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Dr. Toshiyuki Akiyama
Research Institute
Sankyo Co., Ltd.
2-58 Hiromachi 1-Chome
Shinagawa-ku
Tokyo 140-8710
Japan
Email: akiy@shina.sankyo.co.jp
Phone: +81-3-5436-8569