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DOI: 10.1055/s-2000-11130
Three New Lanostane-Type Triterpene Lactones from the Stem Bark of Abies mariesii
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200002/lookinside/thumbnails/10.1055-s-2000-11130-1.jpg)
Abstract
Three new Δ8-lanostane-type triterpene lactones (1), (2) and (3) were isolated from the stem bark of Abies mariesii M. and unambiguously characterized on the basis of spectroscopic and chemical evidence. Chemical modification of compound 1 showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).
Key words
Abies mariesii - Pinaceae - lanostane - 2D NMR - in vitro anti-tumor-promoting activity
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Reiko Tanaka
Department of Medicinal Chemistry
Osaka University of Pharmaceutical Sciences
4-20-1 Nasahara
Takatsuki
Osaka 569-1094
Japan
Email: tanakar@oysun01.oups.ac.jp
Phone: +81-726-90-1084