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Synlett 1999; 1999(1): 159
DOI: 10.1055/s-1999-6184
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Bis(cyclopentadienyl)titanium(III) Chloride

Helen J. Gold*
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
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Publication Date:
31 December 1999 (online)

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Bis(cyclopentadienyl)titanium(III) chloride 1 - Nugent's reagent - exists as a chloride-bridged dimer in its solid state, but dissociates to its monomeric species in the presence of donor solvents (e.g. THF) to afford a loosely solvated `transition-metal-centred-radical'. The very mild nature of Nugent's reagent, and its selective one-electron reduction of epoxides results in its compatibility with highly functionalised compounds. The reactivity of the carbon-centred radical formed by initial C-O homolysis of the epoxide can be tuned depending on the reacting partner.