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Synthesis 1999; 1999(5): 775-778
DOI: 10.1055/s-1999-3463
DOI: 10.1055/s-1999-3463
paper
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Purine Nucleoside Analogues; 9: Benzylation of N 2-Acetyl-8-bromoguanine
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Publication History
Publication Date:
31 December 1999 (online)
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A one-step synthesis of regioisomeric N- and O-benzylated 8-bromoguanines 4, 5, 9, 10 via N 2-acetyl-8-bromoguanine (2) is described. The possibility to prepare 8-oxo- and 8-chloroguanine derivatives 3, 11, 12 from the same compound 2 is demonstrated. 1H and 13C NMR spectra are used to locate the sites of aralkylation.
N 2-acetyl-8-bromoguanine - benzylation - regioisomers