Synthesis 1999; 1999(5): 885-897
DOI: 10.1055/s-1999-3462
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Development of Novel Reactions Using Hypervalent Iodine(III) Reagents: Total Synthesis of Sulfur-Containing Pyrroloiminoquinone Marine Product, (±)-Makaluvamine F

Yasuyuki Kita* , Masahiro Egi, Takeshi Takada, Hirofumi Tohma
  • *Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan; Fax +81(6)68 79 82 29; E-mail: kita@phs.osaka-u.ac.jp
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Publication History

Publication Date:
31 December 1999 (online)

Novel and efficient intramolecular nucleophilic substitution reactions of phenol ethers using activated hypervalent iodine species have been developed and their application to the total synthesis of strongly cytotoxic makaluvamine F (1), a member of sulfur-containing pyrroloiminoquinone marine products, is described.