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Synlett 1999; 1999(9): 1441-1443
DOI: 10.1055/s-1999-3167
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A Regio and Stereospecific Synthesis of Carbacephem Antibiotics

Gema Ruano* , Josefa Anaya, Manuel Grande
  • *Departamento de Química Orgánica, Universidad de Salamanca, E-37008 Salamanca, Spain; Fax + 34 23 29 45 74; E-mail: janay@gugu.usal.es
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Publication Date:
31 December 1999 (online)

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In this article we report a short and practical route to chiral carbacephems 1 based on an asymmetric Staudinger reaction for building the β-lactam ring, and on a tandem elimination-conjugate addition for making the second ring.

d-glucosamine - asymmetric Staudinger reaction - β-lactam - tandem ring-closure - carbacephem